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Main article: Prayer
Prayer is a skill which works best alongside your primary combat style (be it Magic, Melee or Ranged). Through the use of prayers you can temporarily increase stats, reduce damage, and protect against various attacks.
Each of the prayers can be turned on or off individually, and while in use will grant your character the advantages as listed above. To activate a prayer, left-click the icon in question and it will have a light appear around it, which lets you know that the prayer is in use. To deactivate it, simply click on it again.
So you can only use one attack-method prayer at a time (Attack and Strength combined count as melee-style here), and only one Defence prayer.
Any active prayers are displayed on the combat interface.
For a list of all standard prayers see Prayers.
The curse list has the same functionality as the prayer list.
Cures are available after completing The Temple at Senntisten and are focused more on damaging and weakening your enemy than making yourself more resilient as prayers are.
For a list of all curses see Curses.
While any of your prayers or curses are active, your prayer points will start to slowly drain towards zero. The more prayers/curses you use at once and the more powerful they are, the faster your points will be drained. When you run out of prayer points, all prayers/curses will automatically stop working and you will need to either pray at an altar or drink a Prayer potion before you are able to use them again (if you die this will also reset them).